De Novo Designed Ru(II) Metallacycle as a Microenvironment-Adaptive Sonosensitizer and Sonocatalyst for Multidrug-Resistant Biofilms Eradication

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成果类型：

期刊论文

作者：

Xu, Yuling;Pang, Yida;Luo, Lishi;Sharma, Amit;Yang, Jingfang;...

通讯作者：

Sun, Y

作者机构：

[Xu, Yuling; Luo, Lishi; Sun, Yao; Pang, Yida; Yang, Jingfang; Li, Chonglu] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

[Luo, Lishi] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

[Sharma, Amit] Amity Univ Punjab, Amity Sch Chem Sci, Dept Phys, Mohali 140306, India.

[Liu, Shuang] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China.

[Zhan, Jianbo] Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Testing, Wuhan, Hubei, Peoples R China.

通讯机构：

[Sun, Y ] C

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

Metallacycle;Sonodynamic therapy;Biofilm microenvironment;Bacterial eradication

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN：

1433-7851

年：

2024

卷：

期：

页码：

e202319966-

DOI：

10.1002/anie.202319966

基金类别：

National Natural Science Foundation of China; National Natural Science Foundation of Hubei Province [2022CFA033]; Fundamental Research Funds for the Central Universities [CCNU22QN007]; Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics [2021005, CCNU-IACUC-2023-001]; Hubei Provincial Center for Disease Control and Prevention [HBCDC-IACUC-202310210]; [22022404]; [22074050]; [22374055]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and the intricate biofilm microenvironment (BME), substantially hamper the therapeutic efficacy against biofilm infections. To address the bottlenecks, we innovatively design a Ru(II) metallacycle-based sonosensitizer/sonocatalyst (named Ru-A3-TTD) to enhance the potency of sonotherapy by employing molecular engineering strategies tailored to BME. Our approach involves augmentin...

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De Novo Designed Ru(II) Metallacycle as a Microenvironment-Adaptive Sonosensitizer and Sonocatalyst for Multidrug-Resistant Biofilms Eradication

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