Novel bright-emission small-molecule NIR-II fluorophores for: In vivo tumor imaging and image-guided surgery

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成果类型：

期刊论文

作者：

Sun, Yao;Ding, Mingmin;Zeng, Xiaodong;Xiao, Yuling;Wu, Huaping;...

通讯作者：

Hong, Xuechuan

作者机构：

[Ding, Mingmin; Qu, Chunrong; Ding, Bingbing; Zhou, Hui; Sun, Yao; Zeng, Xiaodong; Wu, Huaping; Hou, Wei; Xiao, Yuling; Hong, Xuechuan] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Key Lab Dev Originated Dis, State Key Lab Virol,Key Lab Combinatorial Biosynt, Wuhan 430071, Peoples R China.

[Sun, Yao] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.

[Cheng, Zhen] Stanford Univ, Dept Radiol, Bio X Program, MIPS, Stanford, CA 94305 USA.

[Hong, Xuechuan; Er-bu, A. G. A.] Tibet Univ, Med Coll, Lasa 850000, Peoples R China.

[Zhang, Yejun] Suzhou NIR Opt Technol Co Ltd, Suzhou 215123, Peoples R China.

通讯机构：

[Hong, Xuechuan] W

[Hong, Xuechuan] T

Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Key Lab Dev Originated Dis, State Key Lab Virol,Key Lab Combinatorial Biosynt, Wuhan 430071, Peoples R China.

Tibet Univ, Med Coll, Lasa 850000, Peoples R China.

语种：

英文

期刊：

CHEMICAL SCIENCE

ISSN：

2041-6520

年：

2017

卷：

期：

页码：

3489-3493

DOI：

10.1039/c7sc00251c

基金类别：

NSFCNational Natural Science Foundation of China (NSFC) [81573383, 21390402, 81301268]; NSFHPNational Science Foundation (NSF) [2014CFB704]; ISTCPC [2015DFA30440, 2014CFB30020]; Major Project of Technology Innovation Program of Hubei Province [2016ACA126]; Applied Basic Research Programs of Scientific and Technologic Council of Suzhou [SYG201521]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20160387]; Beijing Nova Plan Z [131107000413063]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY ≈ 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible N...

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Novel bright-emission small-molecule NIR-II fluorophores for: In vivo tumor imaging and image-guided surgery

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