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成果类型:
期刊论文
作者:
Yang, Ge;Gong, Cunyi;Zheng, Xinyue;Hu, Fei;Liu, Jie;...
通讯作者:
Li, R
作者机构:
[Liu, Jie; Li, Min; Li, R; Chen, Xinyue; Li, Rui; Yang, Ge; Hu, Fei; Gong, Cunyi; Zheng, Xinyue; Wang, Tian] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
[Liu, Jie] Cent China Normal Univ, Primary Sch, Wuhan 430079, Peoples R China.
[Wang, Tian] Huaqiao Univ, Coll Civil Engn, Xiamen 361021, Peoples R China.
[Zhu, Zhihong] Cent China Normal Univ, Inst Nanosci & Nanotechnol, Coll Phys Sci & Technol, Wuhan 430079, Peoples R China.
[Zhang, Ling] Wuhan Univ Sci & Technol, Acad Nutr & Hlth, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China.
通讯机构:
[Li, R ] C
Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Combined effect;DEHP;Heat shock response;Immature mice;Neurotoxicity;Polypropylene microplastics
期刊:
Environmental Pollution
ISSN:
0269-7491
年:
2023
卷:
336
页码:
122406
基金类别:
This research was financially supported by the National Natural Science Foundation of China ( 42077403 ) and self-determined research funds of CCNU from the colleges' basic research and operation of MOE ( CCNU18JCXK07 and CCNU19TS066 ). Graphic abstract and diagrams were created with BioRender.com .
机构署名:
本校为第一且通讯机构
院系归属:
物理科学与技术学院
生命科学学院
摘要:
Studies have shown that exposure to either microplastics (MPs) or di-(2-ethylhexyl) phthalic acid (DEHP) alone can cause neurotoxicity in animals, but it remains uncertain whether and to what extent co-exposure to these two substances, which often occur together in reality, can also induce neurotoxicity. This study aimed to investigate the neurotoxicity and molecular mechanisms of combined exposure to DEHP and polypropylene microplastics (synthetic PP-MPs were used), the microplastics most commonly encountered by young children, in immature mice. The results showed that exposure to PP-MPs and/...

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