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Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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成果类型:
期刊论文
作者:
Tang, Yuchen*;Zheng, Xingxing;Gao, Tingjuan
通讯作者:
Tang, Yuchen;Gao, TJ
作者机构:
[Tang, Yuchen; Gao, Tingjuan; Zheng, Xingxing] Cent China Normal Univ, Coll Chem, China Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Tang, YC; Gao, TJ ] C
Cent China Normal Univ, Coll Chem, China Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
期刊:
研究(英文)
ISSN:
2096-5168
年:
2023
卷:
6
页码:
0136
基金类别:
National Natural Science Foundation of China [22076058]; Central China Normal University [CCNU210-31102]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
High-throughput assays play an important role in the fields of drug discovery, genetic analysis, and clinical diagnostics. Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay, practically, the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction conditions. This challenge results in either inaccurate or insufficient decoding outputs. Here, we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-th...

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