期刊论文

Liu, Zheng;Guo, Jun

英文

CHEMISTRY-AN ASIAN JOURNAL

1861-4728

2019

14

12

2116-2121

10.1002/asia.201900448

We are grateful to the National Key Research and Development Program of China (No. 2017YFA0505200), the National Natural Science Foundation of China (Nos. 21772056 and 21402058), Wuhan Bureau of Science and Technology (2018060401011323), the self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (Nos. CCNU18TS011 and CCNU19QN068), Program of Introducing Talents of Discipline to Universities of China (111 program, B17019), the Research Fund of East China University of Technology (No. DHBK2017114), and Chemical Biology Center of CCNU.

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The tumor-associated antigen mucin 1 (MUC1) has been pursued as an attractive target for cancer immunotherapy, but the poor immunogenicity of the endogenous antigen hinders the development of vaccines capable of inducing effective anti-MUC1 immunodominant responses. Herein, we prepared synthetic anti-MUC1 vaccines in which the hydrophilic MUC1 antigen was N-terminally conjugated to one or two palmitoyl lipid chains (to form amphiphilic Pam-MUC1 or Pam2-MUC1). These amphiphilic lipid-tailed MUC1 antigens were self-assembled into liposomes contai...