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Phenethylamine@Pillar[5]arene Biointerface for Highly Enantioselective Adsorption of Protein

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成果类型:
期刊论文
作者:
Yan, Hewei;Ma, Junkai;Zhu, Fei;Quan, Jiaxin;Dhinakaran, Manivannan Kalavathi;...
通讯作者:
Li, Haibing
作者机构:
[Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Quan, Jiaxin; Yan, Hewei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China.
通讯机构:
[Li, Haibing] C
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
pillar[5]arene;chiral;biointerface;adsorption;proteins
期刊:
CHEMISTRY-AN ASIAN JOURNAL
ISSN:
1861-4728
年:
2020
卷:
15
期:
7
页码:
1025-1029
基金类别:
This work was financially supported by the National Key Research and Development Program of China (2018YFD0200102), the National Natural Science Foundation of China (21772055, 21572076, 21911530178), the 111 Project (B17019) and Self-determined research funds of CCNU from the colleges’ basic research and operation of MOE.
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
In the life system, the biointerface plays an important role in cell adsorption, platelet adsorption and activation. Therefore, the study of protein adsorption on the biointerface is of great significance for understanding life phenomena and treatment in vitro. In this paper, a chiral biointerface was constructed by the virtue of host-guest interaction between a water-soluble pillar[5]arene (WP5) and phenethylamine (PEA) over a gold surface for adsorption of lysozyme proteins. From the experimental results it was identified that the host-guest ...

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