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Ultraviolet/Visible Light Regulated Protein Transport Gate Constructed by Pillar[6]arene-based Host-Guest System

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成果类型:
期刊论文
作者:
Yang, Lei;Zhang, Fan;Chen, Chunxiu;Liu, Zhisheng;Liu, Lu;...
通讯作者:
Li, Haibing(lhbing@mail.ccnu.edu.cn)
作者机构:
[Chen, Chunxiu; Yang, Lei; Liu, Zhisheng; Li, Haibing; Liu, Lu] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
[Zhang, Fan] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Coll Chem & Chem Engn, Minist Educ,Key Lab Synth & Applicat Organ Funct, Wuhan 430062, Peoples R China.
通讯机构:
[Prof. Haibing Li] K
Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China
语种:
英文
关键词:
BSA;host-guest.;light-responsive;pillararene;protein transport
期刊:
CHEMISTRY-AN ASIAN JOURNAL
ISSN:
1861-4728
年:
2022
卷:
17
期:
14
页码:
e202200455-
基金类别:
This work was financially supported by the National Key Research and Development Program (2021YFA0716702), the National Natural Science Foundation of China (22071074, 21772055), the 111 Project (B17019) and Self‐determined research funds of CCNU from the colleges’ basic research and operation of MOE.
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
Protein transport is an interesting and intrinsic life feature that is highly relevant to physiology and disease in living beings. Herein, inspired by nature, based on the supramolecular host-guest interaction, we have introduced the classical azobenzene light switches and L-phenylalanine derived pillar[6]arene (L-Phe-P6) into the artificial nanochannel to construct light-responsive nanochannels that could regulate protein transport effectively under the control of ultraviolet (UV) and visible (Vis) light. The light-controlled distribution of L...

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