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Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide

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成果类型:
期刊论文
作者:
Qu, Ren-Yu;Nan, Jia-Xu;Yan, Yao-Chao;Chen, Qiong;Ndikuryayo, Ferdinand;...
通讯作者:
Lin, Hong-Yan;Yang, Guang-Fu
作者机构:
[Ndikuryayo, Ferdinand; Yang, Guang-Fu; Yang, Wen-Chao; Lin, HY; Yang, GF; Wei, Xue-Fang; Nan, Jia-Xu; Qu, Ren-Yu; Yan, Yao-Chao; Chen, Qiong; Lin, Hong-Yan] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Lin, HY; Yang, GF] C
Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
quinazoline-2;4-dione;hydroxyphenylpyruvate dioxygenase;hydrophobic interaction;lead optimization;herbicide
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2021
卷:
69
期:
1
页码:
459-473
基金类别:
The authors thank Shandong Cynda Chemical Co., Ltd. for the help in the screening of herbicidal activity. This research was supported by the National Key R&D Program (no. 2018YFD0200100), National Natural Science Foundation of China (nos. 31901910, 21837001, and 21772058), and China Postdoctoral Science Foundation (no. 2018M642880).
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) has been recognized as one of the most promising targets in the field of herbicide innovation considering the severity of weed resistance currently. In a persistent effort to develop effective HPPD-inhibiting herbicides, a structure-guided strategy was carried out to perform the structural optimization for triketone-quinazoline-2,4-diones, a novel HPPD inhibitor scaffold first discovered in our lab. Herein, starting from the crystal structure of Arabidopsis thaliana (At)HPPD complexed wi...

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