期刊论文

中文

现代预防医学

1003-8507

2004

31

5

661-663

10.3969/j.issn.1003-8507.2004.05.006

国家“十五”科技攻关课题 （2 0 0 1BA70 4B0 1）；

本校为第一机构

目的:探讨用眨眼频率代替眼刺激感觉强度,作为反映气态甲醛对人体眼部刺激作用的生物标志.方法:采用控制暴露人体实验.通过对10名受试者采取眼局部对气态甲醛的暴露(约0、1.0、2.0和3.0 mg/m3,5 min),测量了受试者的眨眼频率和眼刺激感觉强度.结果:甲醛暴露水平与眨眼频率之间(r=0.980,P＜0.05);甲醛暴露水平与眼刺激感觉强度之间(r=0.985,P＜0.05)均呈暴露-剂量关系,两种生物标志之间有高度相关性(r=0.985,P＜0.05).结论眨眼频率作为反映刺激作用的生物标志比眼部刺激感觉强度更为客观,因而更具有科学性.

Objective:To investigate the blinking frequency as a biomarker for the irritation responses of the human body whose eyes were exposed to the formaldehyde.Methods:The controlled human exposure experiment was applied in this study.There vere 10 subjects whose eyes were exposed to gaseous formaldehyde(1.0,2.0 and 3.0 mg/m3,for 5minutes),and the blinking frequency and irritant intensity of their eyes were measured at the same time.Results:There are dose-deqendent relationship between blinking frequency and formaldehyde levels(r=0.980,P