Prostate-specific antigen (PSA) is a characteristic serum biomarker for screening prostate cancer, which benefits the prostate cancer diagnosis at an early stage. At present, the reported strategies for PSA detection are mainly simplex signal readout, inevitably limiting the inherent accuracy and reliability of the involved bioassay. In this work, ionic liquid functionalized Cu@Cu2O aerogels (IL-Cu@Cu2O) with the photoelectric response and enzyme-mimicking activity are used to construct a dual-mode biosensing platform toward PSA with Ag nanopar...