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Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

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成果类型:
期刊论文
作者:
Ma, Ping;Luo, Qing;Chen, Jiaoe;Gan, Yaping;Du, Juan;Ding, Shumao;Xi, Zhuge;Yang, Xu
通讯作者:
Yang, X.
作者机构:
[Chen, Jiaoe; Gan, Yaping; Ma, Ping] Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning, Peoples R China.
[Luo, Qing; Yang, Xu; Du, Juan; Ma, Ping; Ding, Shumao] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.
[Xi, Zhuge] Tianjin Inst Hlth & Environm Med, Tianjin, Peoples R China.
通讯机构:
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Laboratory of Environmental Sciences, Central China Normal University, Building 5, No 152 Luo-Yu Road, China
语种:
英文
关键词:
8-hydroxy-2'-deoxyguanosine;DNA-protein crosslinks;Fe3O4-nanoparticles;glutathione;malondialdehyde;reactive oxygen species
期刊:
International Journal of Nanomedicine
ISSN:
1178-2013
年:
2012
卷:
7
页码:
4809-4818
基金类别:
Chinese National Program for High Technology Research and Development (863 Program) [2006AA03Z330]; Chinese National Program for Fundamental Research and Development (973 Program)National Basic Research Program of China [2010CB933904]
机构署名:
本校为其他机构
院系归属:
城市与环境科学学院
生命科学学院
摘要:
Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice Ping Ma,1,2,* Qing Luo,2,* Jiaoe Chen,1 Yaping Gan,1 Juan Du,2 Shumao Ding,2 Zhuge Xi,3 Xu Yang2 1College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, People's Republic of China; 2Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, People's Republic of China; 3Tianjin Institute of Health and Environmental Medicine, Tianjin, People's Republic of China*These authors contributed equally to this workAbstract: Because of its unique magnetic properties, the iron oxide (Fe3O4) nanoparticle has been widely exploited and its application in various fields has promised immense benefits. However, doubts exist over the use of Fe3O4-nanoparticles in human beings. Thus, the aim of the current study was to find out the potential safety range of medical use. Twenty-five Kunming mice were exposed to Fe3O4-nanoparticles via intraperitoneal injection daily for 1 week at doses of 0, 5, 10, 20, and 40 mg/kg. Hepatic and renal tissues were sliced for physiological observation. Injuries were observed in the high-dose groups (20 and 40 mg/kg) compared with the control group (0 mg/kg). Biomarkers of reactive oxygen species, glutathione, malondialdehyde, DNA-protein crosslinks, and 8-hydroxy-2'-deoxyguanosine in the hepatic and renal tissues were detected. Injury to tissues and oxidative damage to cells at the molecular level was found. The safest dose recommended from the results of this study is 5 mg/kg, as we believe this to be an upper limit balancing the benefits and risks for sub-long-term exposure.Keywords: Fe3O4-nanoparticles, reactive oxygen species, glutathione, malondialdehyde, DNA-protein crosslinks, 8-hydroxy-2'-deoxyguanosine

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