Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

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成果类型：

期刊论文

作者：

Ma, Ping;Luo, Qing;Chen, Jiaoe;Gan, Yaping;Du, Juan;...

通讯作者：

Yang, Xu

作者机构：

[Chen, Jiaoe; Gan, Yaping; Ma, Ping] Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning, Peoples R China.

[Luo, Qing; Yang, Xu; Du, Juan; Ma, Ping; Ding, Shumao] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.

[Xi, Zhuge] Tianjin Inst Hlth & Environm Med, Tianjin, Peoples R China.

[Yang, Xu] Huazhong Normal Univ, Coll Life Sci, Lab Environm Sci, Bldg 5,152 Luo Yu Rd, Wuhan 430079, Peoples R China.

通讯机构：

[Yang, Xu] H

Huazhong Normal Univ, Coll Life Sci, Lab Environm Sci, Bldg 5,152 Luo Yu Rd, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

8-hydroxy-2'-deoxyguanosine;DNA-protein crosslinks;Fe3O4-nanoparticles;glutathione;malondialdehyde;reactive oxygen species

期刊：

INTERNATIONAL JOURNAL OF NANOMEDICINE

ISSN：

1178-2013

年：

2012

卷：

页码：

4809-4818

DOI：

10.2147/IJN.S34349

基金类别：

Chinese National Program for High Technology Research and Development (863 Program) [2006AA03Z330]; Chinese National Program for Fundamental Research and Development (973 Program)National Basic Research Program of China [2010CB933904]

机构署名：

本校为通讯机构

院系归属：

城市与环境科学学院

生命科学学院

摘要：

Because of its unique magnetic properties, the iron oxide (Fe3O4) nanoparticle has been widely exploited and its application in various fields has promised immense benefits. However, doubts exist over the use of Fe3O4-nanoparticles in human beings. Thus, the aim of the current study was to find out the potential safety range of medical use. Twenty-five Kunming mice were exposed to Fe3O4-nanoparticles via intraperitoneal injection daily for 1 week at doses of 0, 5, 10, 20, and 40 mg/kg. Hepatic and renal tissues were sliced for physiological obs...

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Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

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