Mechanisms of exacerbation of Th2-mediated eosinophilic allergic asthma induced by plastic pollution derivatives (PPD): A molecular toxicological study involving lung cell ferroptosis and metabolomics

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成果类型：

期刊论文

作者：

Wei, Huaqin;Lu, Surui;Chen, Mingqing;Yao, Runming;Yan, Biao;...

通讯作者：

Ma, P

作者机构：

[Song, Xiaoli; Wu, Yang; Li, Qing; Lu, Surui; Li, Mengcheng; Yang, Xu; Wei, Huaqin; Yan, Biao; Ma, Ping] Hubei Univ Sci & Technol, Xianning Med Coll, Key Lab Environm Related Dis & One Hlth, Xianning 437100, Peoples R China.

[Chen, Mingqing] Cent China Normal Univ, Coll Life Sci, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Yao, Runming] Chongqing Univ, Joint Int Res Lab Green Bldg & Built Environm, Minist Educ, Chongqing 400045, Peoples R China.

[Wu, Yang; Yang, Xu; Yan, Biao; Ma, Ping] Hubei Ind Technol Res Inst Intelligent Hlth, Xianning 437100, Peoples R China.

[Yang, Xu] Dali Univ, Inst Eastern Himalaya Biodivers Res, Dali 671003, Yunnan, Peoples R China.

通讯机构：

[Ma, P ] H

Hubei Univ Sci & Technol, 88 Xianning Ave, Xianning 437100, Peoples R China.

语种：

英文

关键词：

Allergic asthma;Deferoxamine (DFO);Ferroptosis;Metabolomics analysis;NFκB pathway;Oxidative stress;Plastic pollution derivatives (PPD)

期刊：

Science of The Total Environment

ISSN：

0048-9697

年：

2024

卷：

946

页码：

174482

DOI：

10.1016/j.scitotenv.2024.174482

基金类别：

National Natural Science Foundation of China [42177416, 52278090]; Key Special Project for Social Devel- opment R & D of Xianning City Science and Technology Program [2021SFYF007, 2023SFYF095]; Scientific Research Innovative Team of Hubei University of Science and Technology [2023T08]

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本校为其他机构

院系归属：

生命科学学院

摘要：

Polystyrene microplastics (PS-MP) and dibutyl phthalate (DBP) are plastic pollution derivatives (PPDs) commonly found in the natural environment. To investigate the effects of PPD exposure on the risk of allergic asthma, we established a PPD exposure group in a mouse model. The dose administered for PS-MP was 0.1mg/d and for DBP was 30mg/kg/d, with a 5-week oral administration period. The pathological changes of airway tissue and the increase of oxidative stress and inflammatory response confirmed that PPD aggravated eosinophilic allergic asthm...

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Mechanisms of exacerbation of Th2-mediated eosinophilic allergic asthma induced by plastic pollution derivatives (PPD): A molecular toxicological study involving lung cell ferroptosis and metabolomics

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