Immune-check blocking combination multiple cytokines shown curative potential in mice tumor model

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成果类型：

期刊论文

作者：

Su, Hongxia;Geng, Hui;Cai, Linkang;Xu, Minjie;Xing, Wenpin;...

通讯作者：

Li, YK;Liu, BL

作者机构：

[Su, Hongxia; Li, Yankun] Hubei Univ Sci & Technol, Sch Pharm, Xianning, Peoples R China.

[Xu, Minjie; Xing, Wenpin; Geng, Hui] Huazhong Normal Univ, Sch Life Sci, Wuhan, Peoples R China.

[Long, Wei; Liu, Binlei; Cai, Linkang] Wuhan Binhui Biopharmaceut Co Ltd, Wuhan, Peoples R China.

[Liu, Binlei; Liu, Biao] Hubei Univ Technol, Wuhan, Peoples R China.

[Li, Yankun; Li, YK] Hubei Univ Sci & Technol, Coll Pharm, Hubei Engn Res Ctr Hubei Specialty Chinese Med, Xianning 437100, Peoples R China.

通讯机构：

[Liu, BL ; Li, YK ] H

Hubei Univ Sci & Technol, Coll Pharm, Hubei Engn Res Ctr Hubei Specialty Chinese Med, Xianning 437100, Peoples R China.

Hubei Univ Technol, Coll Bioengn, Wuhan 430068, Peoples R China.

语种：

英文

关键词：

GM-CSF;IL-12;IL-2/15;PD-1v;tumor immunity

期刊：

Cancer Medicine

ISSN：

2045-7634

年：

2023

卷：

期：

页码：

13573-13585

DOI：

10.1002/cam4.6053

基金类别：

Fundamental Research Funds for the Central University of Central China Normal University [CCNU20TS02112]; Innovative Research Group Project of the National NAtural Science FOundation of China [32170906]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

The combination of immune check blockade and multiple cytokine therapy can significantly activate the body's immune response and inhibit tumor growth. Our manuscript provides a paradigm for future tumor immunotherapy. Abstract Objective In order to ensure the stable transcription of target genes, we constructed a eukaryotic high expression vector carrying an immune‐check inhibitor PD‐1v and a variety of cytokines, and studied their effects on activating immune response to inhibit tumor growth. Methods A novel eukaryotic expression plasmid vec...

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Immune-check blocking combination multiple cytokines shown curative potential in mice tumor model

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