期刊论文

Chen, Mingqing

英文

Toxicology

0300-483X

2021

461

152910

10.1016/j.tox.2021.152910

Author statement The author's contribution and role to this work are as follows: Jin Xie: Investigation, Validation, Methodology, Writing- Original draft preparation. Qi Han: Methodology, Investigation. Zhaolan Wei: Methodology, Investigation. Shuwei Wang: Methodology, Investigation. Yunyi Wang: Methodology, Investigation. Mingqing Chen: Conceptualization, Methodology, Writing- Reviewing and Editing, Project administration, acquisition, Data Curation, Supervision. Acknowledgments This study was supported by Self determined Research Funds of CCNU from the colleges’ basic research and operation of MOE (CCNU20TS020) and CCNU Graduate Education Innovation Project (2020CXZZ067).

本校为第一且通讯机构

Autism is thought to be associated with both environmental and genetic factors. Phenanthrene (Phe) makes up a relatively high proportion of the low-ring polycyclic aromatic hydrocarbons. However, the association between exposure to Phe and Autism remain unclear. In this study, the effect and mechanisms of phenanthrene exposure on autistic behavior were investigated. Three-week-old male Kunming mice were exposed to doses of 5, 50, or 500 mu g/kg/d Phe for 22 days. Exposure to phenanthrene induced a marked decrease in the activity of the mice in the central area in the open field test, and cause...