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Association between Glutathione and GSNO Reductase in Formaldehyde Inhaled Mice Lungs

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成果类型:
期刊论文、会议论文
作者:
Cao Yi;Wu Kai;Yang Guangtao;Yang Xu*
通讯作者:
Yang Xu
作者机构:
[Cao Yi; Yang Xu; Wu Kai; Yang Guangtao] Huazhong Normal Univ, Coll Life Sci, Lab Environm Sci, Wuhan, Peoples R China.
通讯机构:
[Yang Xu] H
Huazhong Normal Univ, Coll Life Sci, Lab Environm Sci, Wuhan, Peoples R China.
语种:
英文
关键词:
Asthma;Formaldehyde;GSNO reductase;Oxidative stress
期刊:
2009 3RD INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING, VOLS 1-11
年:
2009
页码:
4159-4162
会议名称:
The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)
会议论文集名称:
The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)论文集
会议时间:
2009-06-11
会议地点:
北京
会议赞助商:
IEEE生物医学工程协会
机构署名:
本校为第一且通讯机构
院系归属:
城市与环境科学学院
生命科学学院
摘要:
Accumulating evidences demonstrate that the channeling of nitric oxide (NO) into S-nitrothiols (SNOs) plays a pivotal role in mediating NO actions. Recent work suggests that GSNO reductase (GSNOR), an enzyme responsible for SNO metabolism, is abnormally elevated under asthmatic conditions. To study GSNOR induction in mice lung, male Kun Ming mice were exposed to gaseous formaldehyde (FA) of 0, 3.0 mg/m~3 and 3.0 mg/m~3 with α-lipoic acid (LA) injection, continuously for 3d. After exposure, GSNOR activity and transcription were examined, and GS...
摘要(中文):
Accumulating evidences demonstrate that the channeling of nitric oxide (NO) into S-nitrothiols (SNOs) plays a pivotal role in mediating NO actions. Recent work suggests that GSNO reductase (GSNOR), an enzyme responsible for SNO metabolism, is abnormally elevated under asthmatic conditions. To study GSNOR induction in mice lung, male Kun Ming mice were exposed to gaseous formaldehyde (FA) of 0, 3.0 mg/m3 and 3.0 mg/m3 with 僴-lipoic acid (LA) injection, continuously for 3d. After exposure, GSNOR activity and transcription were examined, and GS...

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