Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment

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成果类型：

期刊论文

作者：

Mei, Yufei;Duan, Chunli;Li, Xiaoxiao;Zhao, Yun;Cao, Fenghua;...

通讯作者：

Yang, Xu;Tong, Zhiqian

作者机构：

[Cao, Fenghua; Li, Xiaoxiao; Yang, Xu; Zhao, Yun; Shang, Shuai; Ding, Shumao; Mei, Yufei] Cent China Normal Univ, Coll Life Sci, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Feng, Xueyan; Yue, Xiangpei; Jia, Jianping; Shen, Luxi; Mei, Yufei; Tong, Zhiqian] Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China.

[Yang, Hui; Gao, Ge; Duan, Chunli] Capital Med Univ, Dept Neuobiol, Beijing 100069, Peoples R China.

通讯机构：

[Yang, Xu; Tong, Zhiqian] C

Cent China Normal Univ, Coll Life Sci, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China.

语种：

英文

关键词：

">l-glutathione;formaldehyde (FA);melatonin (MT);oxidative stress;reactive oxygen species;spatial memory

期刊：

International Journal of Environmental Research and Public Health

ISSN：

1661-7827

年：

2016

卷：

期：

页码：

258-

DOI：

10.3390/ijerph13030258

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 31171080, 51136002]; Scientific Research Common Program of Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [KM201510025014]; Natural Scientific Foundation of CCMU [2015ZR31]; Beijing institute for brain disorders [0000040103]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Individuals afflicted with occupational formaldehyde (FA) exposure often suffer from abnormal behaviors such as aggression, depression, anxiety, sleep disorders, and in particular, cognitive impairments. Coincidentally, clinical patientswithmelatonin (MT) deficiency also complain of cognitive problems associated with the above mental disorders. Whether and how FA affects endogenousMT metabolism and induces cognitive decline need to be elucidated. To mimic occupational FA exposure environment, 16 healthy adultmalemice were exposed to gaseous FA ...

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Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment

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