期刊论文

Yang, X.(yangxu@mail.ccnu.edu.cn)

中文

中国环境科学

1000-6923

2013

33

7

1323-1327

D20122803:湖北省教育厅科学技术研究项目 51136002:国家自然科学基金 201210927036:国家级大学生创新创业训练计划项目

本校为通讯机构

以昆明小鼠为受试动物,随机分为6组,包括1个阴性对照组、3个氯氰菊酯染毒组、1个维生素E组和1个高剂量氯氰菊酯加维生素E组,染毒组按10,20,40mg/kg 3个剂量水平,维生素E的剂量为100mg/kg,灌胃染毒小鼠7d.以脑组织匀浆测定活性氧(ROS)、还原型谷胱甘肽(GSH)和丙二醛(MDA)的含量;以脑组织细胞测定DNA-蛋白质交联(DPC)系数.随着氯氰菊酯染毒剂量的升高,脑组织的ROS、MDA含量和DPC系数逐渐上升,GSH含量逐渐降低,各指标呈一定的剂量-效应关系.染毒剂量≥20mg/kg时,ROS含量(841.3±100.34)、GSH含量[(12.54±1.316)nmol/L]和DPC系数(0.054±0.004)有显著差异(P

Kunming mice were randomly grouped into six groups and orally administered with drugs daily for a week;the groups included one solvent control group, three cypermethrin groups, one high dose cypermethrin plus vitamin E protection group and one vitamin E group. The exposure doses of cypermethrin groups were 10, 20 and 40 mg/kg respectively. Some brain tissues were then made into homogenates for the measurement of ROS (reactive oxygen species), GSH (glutathione) and MDA (Malondialdehyde) contents. Meanwhile, DPC (DNA-protein Crosslink) coefficients were detected from brain cell suspension. The b...