期刊论文

Wu, Yang

中文

中国环境科学

1000-6923

2014

34

11

2958-2963

D20122803:湖北省教育厅科学技术研究项目 201210927036:国家级大学生创新创业训练计划项目

本校为其他机构

以昆明小鼠为受试动物,随机分为6组,包括1个阴性对照组、3个氯氰菊酯染毒组、1个维生素E组和1个高剂量氯氰菊酯加维生素E组,染毒组按10,20,40mg/kg水平,维生素E的剂量为100mg/kg,灌胃染毒小鼠7d.以肾组织匀浆测定活性氧(ROS)、还原型谷胱甘肽(GSH)、丙二醛(MDA)和8-羟基脱氧鸟苷(8-OHdG)的含量；以肾组织细胞测定 DNA-蛋白质交联(DPC)系数.随着氯氰菊酯染毒剂量的升高,肾组织的ROS、MDA、8-OHdG含量和DPC系数逐渐上升,GSH含量逐渐降低,各指标呈一定的剂量-效应关系.染毒剂量为20mg/kg 时,MDA 和8-OHdG 含量差异有统计学意义(P

Kunming mice were randomly grouped into six groups and treated with orally administered drugsona daily base for a week. The groups included one solvent control group, three cypermethrin groups, one high dose cypermethrin plus vitamin E protection group and one vitamin E group. The exposure doses of cypermethrin groups were 10, 20 and 40mg/kg respectively. Some kidney tissues were then made into homogenates for the measurement of reactive oxygen species (ROS), glutathione (GSH), 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) conte...