In order to explore the effect of a new plasticizer-di-isononyl phthalate (DINP) on mice allergic skin inflammation, we used skin exposure method. Fifty six male Balb/C mice were divided into seven groups, in which four groups and exposed to 0, 1.4, 14 and 140 mg/kg DINP, two other groups administrated antioxidant melatonin were set to explore oxidative stress effects, and one group was set as saline control. After exposure, the indexes of ear swelling and the weight difference of bilateral ear were determined, and we observed the pathology change through the ear pathology slice. The biomarker...
