期刊论文

Ding, Shu-Mao(dingsm@mail.ccnu.edu.cn)

中文

中国环境科学

1000-6923

2017

37

12

4751-4762

10.3969/j.issn.1000-6923.2017.12.041

21577045:国家自然科学基金 21507026:国家自然科学基金

本校为第一且通讯机构

为探讨甲醛职业气态暴露和邻苯二甲酸二乙基己酯(DEHP)经口灌胃联合染毒对小鼠学习记忆能力的影响,本实验以雄性昆明小鼠为研究对象,开展甲醛与DEHP职业暴露实验研究.实验分组为:(1)对照组;(2)FA(甲醛)组:0.5,1,3mg/m~3;(3)DEHP组: 5,50,500mg/kg;(4)联合组:0.5mg/m~3+5mg/kg,1mg/m~3+50mg/kg,3mg/m~3+500mg/kg;(5)阻断组:生理盐水+VE(维生素E)(100mg/mL),FA3.0mg/m~3+VE,DEHP500mg/kg + VE,FA3.0mg/m~3+DEHP500mg/kg+VE.FA组和联合组吸入气态甲醛染毒8h,5+2模式(5d持续暴露,间隔2d,暴露2周),DEHP组和联合组经口灌胃不同浓度的DEHP溶液,持续14d.此外,阻断组每天用100mg/mL的VE灌胃小鼠(灌胃剂量...

To explore the combined toxic effect of formaldehyde and DEHP on learning and memory of mice and the mechanism, Kunming mice were randomly divided into 14groups: (1) the control group;(2) FA (formaldehyde) group: 0.5mg/m3, 1mg/m3, 3mg/m3;(3) DEHP group: 5mg/kg, 50mg/kg, 500mg/kg;(4) the joint exposure: 0.5mg/m3+5mg/kg, 1mg/m3+50mg/kg, 3mg/m3+500mg/kg;(5) VE group: saline+VE (100mg/kg), FA3.0mg/m3+ VE, DEHP500mg/kg + VE, FA3.0mg/m3+ DEHP500mg/kg + VE. The mice of FA and joint exposure groups were exposed to gaseous formaldehyde for 8h everyday (continuous exposure for 5days, interval for two da...