期刊论文

Effect of combined exposure of DIDP and DINP on the immune toxicity in mice

Ding, Shu-Mao(dingsm@mail.ccnu.edu.cn)

中文

中国环境科学

1000-6923

2017

37

2

740-744

10.3969/j.issn.1000-6923.2017.02.047

华中师范大学教育部资助大学生创新实验项目

本校为第一且通讯机构

为了探究增塑剂邻苯二甲酸二异壬酯(DINP)和邻苯二甲酸二异癸酯(DIDP)联合暴露对小鼠免疫系统毒性有无协同作用,实验采用56只SPF级雄性Balb/C小鼠,随机分为7组,用同种浓度(200mg/kg)不同质量配比的DIDP和DINP混合药剂对小鼠进行灌胃,染毒暴露周期为28d.染毒结束后,取耳组织,测定耳肿指数和双耳重量差;取耳组织和血清,检测生物因子IgE,IFN-γ,IL-4等.实验结果显示,DIDP与DINP联合口腔暴露使小鼠皮肤炎症明显加剧(P

In order to study the adjacent benzene two formic acid di isononyl ester (DINP) and adjacent benzene dicarboxylic acid diisodecyl ester (DIDP) combined exposure toxicity effect on immune system in mice with and without cooperativity. The 56SPF BALB/c mice, were randomly divided into 7groups, with the different mass ratio of DIDP and DINP mix of chemicals at the same concentration (200mg/kg) on mice were intragastric exposure, the period was 28days. After the end of exposure, the ear tissues were taken to measure the ear swelling index and ear w...