期刊论文

Li, Rui(ruli@mail.ccnu.edu.cn)

中文

中国环境科学

1000-6923

2018

38

1

361-368

10.19674/j.cnki.issn1000-6923.2018.0042

国家自然科学基金面上资助项目（21577045）；

本校为第一且通讯机构

为研究增塑剂邻苯二甲酸二异癸酯(DIDP)对小鼠学习和记忆能力的影响,以白藜芦醇(Res)作为保护剂,将42只雄性昆明小鼠随机分为6组,每组7只,分别为:生理盐水组、1.5,15,150 mg/(kg·d) DIDP组、20 mg/(kg·d) Res组、150 mg/(kg·d) DIDP+20 mg/(kg·d) Res组.连续灌胃染毒9d,期间同时进行Morris水迷宫实验.第10 d将小鼠处死,取出脑组织,检测活性氧簇(ROS)、谷胱甘肽(GSH)、丙二醛(MDA)、8-羟基脱氧鸟苷(8-OHdG)、肿瘤坏死因子(TNF-α)、白细胞介素1β(IL-1β)的含量.并对小鼠海马体切片进行H&E染色,观察病理变化.结果显示,15,150 mg/(kg·d) DIDP染毒可导致小鼠的学习和记忆能力显著低于对照组,同...

To elucidate the effect of di-iso-decyl phthalate (DIDP) on the learning and memory ability of mice, 42male Kunming mice were divided into 6groups randomly with 7mice in each group, including saline control group, the experimental groups of DIDP (1.5, 15, 150mg/(kg∙d)), 20mg/(kg∙d) Res control group, using as an anti-oxidant, 150mg/(kg∙d) DIDP+20mg/(kg∙d) Res group. During the constant exposure for 9days, the Morris water maze was used to test the abilities of learning and memory of mice. Reactive oxygen species (ROS), glutathione (GSH), malonaldehyde (MDA), 8-hydroxy-2...