期刊论文

Xu Shengzhen

中文

有机化学

0253-2786

2010

30

2

285-288

武汉市学科带头人计划（No.200851430486）； 国家自然科学基金（No.20872043）资助项目；

本校为第一且通讯机构

取代苯乙烯1与KHSO_5在手性催化剂2存在的条件下反应,生成1-芳基环氧化物3,3与1H-1,2,4.***在固体碳酸钾催化下作用,得到手性的1-芳基-2-(1H-1,2,4-***-1-基)乙醇衍生物4.部分4对甾醇14α-脱甲基化酶表现出强结合作用.

Substituted styrene 1 was reacted with KHSO5 in the presence of the chiral catalyst 2 to give aryloxiranes 3, which were subsequently treated with 1H-1,2,4-triazole and potassium carbonate to generate enantioriched 1-aryl-2-(1H-1,2,4-triazol-1-yl)ethanols 4. Some of the triazoles 4 exhibited strong binding interactions with the cytochrome P450-dependent sterol 14α-demethylase (CYP51). triazo...