期刊论文

Liu Jianchao

中文

有机化学

0253-2786

2011

31

8

1208-1212

20372023,20772042:国家自然科学基金 2010CB126100:国家重点基础研究发展计划（973计划） IRT0953:教育部***和创新团队发展计划项目

本校为第一且通讯机构

用邻氨基噻吩腈与乙酰乙酸甲酯为原料,利用串联Aza-Wittig法合成了9个未见文献报道的噻吩并吡啶并嘧啶类化合物,通过IR,1H NMR,EI-MS,元素分析等方法对所合成的化合物进行了结构表征,并初步测定了所合成化合物的杀菌活性.生测结果表明:此类化合物对棉花枯萎(Fusarium oxysporium)、水稻纹枯(Rhizoctonia solani)、小麦赤霉(Gibberella zeae)、苹果轮纹菌(Dothiorella gregaria)、棉花炭疽菌(Colletotrichum gossypii)等5种菌均有一定的抑制活性.其中对苹果轮纹菌抑制活性最好,在浓度为5.0×10-5 g/mL时抑制率为31.80％～82.84％.

A novel facile synthetic method for thienopyridine derivatives was proposed via the reaction of 2-amino-thiophenes with acetoacetic ester and tin tetrachloride under heating. A series of new 2-(amino/ acetoxy)-3-(4- methylphenyl)-thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one derivatives had been designed and synthesized via an aza-Wittig reaction and structually confirmed by IR, 1H NMR, EI-MS techniques, and elemental analysis. Their biological activities were also researched and many of them showed fungicidal activities against Fusarium ...