期刊论文

Liu Jianchao

中文

有机化学

0253-2786

2012

32

10

1925-1929

10.6023/cjoc201204022

National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20372023, 20772042]

本校为第一且通讯机构

选择3-(2-氯-4-三氟甲基苯氧基)苯甲酸为起始原料,经酰氯化,再与乙醇反应成酯,然后和水合肼反应,最后与芳香醛缩合,合成了10个未见文献报道的3-(2-氯-4-三氟甲基苯氧基)苯甲酰腙4。通过IR, ~1H NMR,EI-MS,元素分析等方法对所合成的化合物进行了结构表征。代表化合物4-氯苯亚甲基-3-(2-氯-4-三氟甲基苯氧基)苯甲酰腙(4f)经单晶X衍射证实了结构.并初步测定了所合成化合物的杀菌和除草活性。结果表明:部分测试化合物在50mg/L浓度下对水稻纹枯菌和黄瓜灰霉菌具有优良的抑制效果,在100 mg/L浓度下对油菜和稗草的根显示一定的抑制效果。

A series of new substituted benzaldehyde (or 2-furaldehyde) 3-(2-chloro-4-trifluoromethyl)phenoxy benzoylhydrazones 4 have been designed and synthesized by the reactions of substituted aldehydes with intermediate 3 in 64%∼89% yields. The structures of compounds 4 have been confirmed by 1H NMR, IR, EI-MS and elemental analyses. The structure of 4-chloro-benzaldehyde 3-(2-chloro-4-trifluoromethyl)phenoxy benzoylhydrazone (4f) has been determined by X-ray single crystal diffraction. The results of preliminary bioassay indicated that some compound...