期刊论文

Wang Tao

中文

有机化学

0253-2786

2014

34

1

215-219

10.6023/cjoc201308014

National Basic Research Program of China (973 Program)National Basic Research Program of China [2010CB126100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21172090]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)Program for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT0953]

本校为第一且通讯机构

为了研究O-烷基 α-(取代苯氧乙酰氧基)烃基膦酸衍生物的结构活性关系,以取代苯氧乙酸为起始原料,经氯化亚砜氯化后得中间体2,然后与不同取代的α-羟基烃基膦酸酯(1)反应制备关键中间体3,再与碘化钠或溴化锂反应,合成了14个未见文献报道的O-烷基α-(取代苯氧乙酰氧基)烃基膦酸盐4.通过~1H NMR, IR, MS和元素分析对所合成的化合物进行了结构表征.初步的生物活性测试结果表明:大多数目标化合物具有较好的除草活性或杀菌活性.化合物4a在1.5 kg/ha剂量下对所测单、双子叶植物的抑制率均达到了100%;在50μg/g的剂量下,化合物4h~4m对油菜菌核菌和黄瓜灰霉菌的抑制率达到90%以上.

For the purpose of studying the structure-activity relationship of Ο-aalkyl α-(substituted phenoxyacetoxy) alkylphosphonic derivatives, fourteen novel Ο-aalkyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized by the reactions of key intermediate 3 with NaI or LiBr. The intermediate 3 was prepared by the treatment of α-hydroxyalkylphosphonates 1 with substituted phenoxyacetyl chlorides 2 which could be easily obtained by the reaction of substituted phenoxyacetic acids with excess thionyl chloride. The structures of compounds...