期刊论文

Chen Yu

中文

有机化学

0253-2786

2014

34

11

2362-2369

10.6023/cjoc201405018

Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities [CZY13004]

本校为其他机构

以环己酮为原料, 利用Gewald 反应合成了6个3-烷基-5,6,7,8-四氢苯并[4,5]噻吩并[2,3-d]嘧啶-4-酮衍生物和17个3-亚苄基胺基四氢苯并[4,5]噻吩并[2,3-d]嘧啶-4-酮衍生物, 通过~1H NMR、~(13)C NMR、IR 和MS 对所合成的化合物进行了结构表征, 并对所合成化合物进行了抗肿瘤活性的筛选. 结果表明4个化合物对人鼻咽癌细胞株(KB)和鼻咽鳞癌细胞株(CNE2)两种肿瘤细胞株表现出一定程度的抑制活性.

Six 3-alkyl-5,6,7,8-tetrahydro[4,5]benzothieno[2,3-d]pyrimidin-4-one derivatives and seventeen 3-benzylideneaminotetrahydrobenzo[ 4,5]thieno[2,3-d]pyrimidin-4-one derivatives have been designed and synthesized via Gewald reaction under mild condition. The structures of synthesized compounds were characterized by 1H NMR, 13C NMR, IR and MS. Their antitumor activities were evaluated against human nasopharyngeal carcinoma (KB) and human nasopharyngeal carcinoma (CNE2) cell lines in vitro. These results revealed that four tested compounds showed modera...