At seeming safe concentrations, synergistic effects of PM2.5 and formaldehyde co-exposure induces Alzheimer-like changes in mouse brain

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Xudong;Zhang, Yuchao;Luo, Chen;Kang, Jun;Li, Jinquan;...

通讯作者：

Yang, Xu;Ma, Ping

作者机构：

[Li, Jinquan; Yang, Xu; Kang, Jun; Liu, Xudong; Luo, Chen] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Lab Environm Biomed, Coll Life Sci, Wuhan, Hubei, Peoples R China.

[Zhang, Yuchao; Liu, Xudong] Moutai Coll, Dept Food Sci & Engn, Renhuai, Peoples R China.

[Ma, Ping] Hubei Univ Sci & Technol, Sch Basic Med Sci, Res Ctr Basic Med Sci, Xianning, Peoples R China.

[Li, Jinquan; Wang, Kun] NYU, Sch Med, Tuxedo Pk, NY USA.

通讯机构：

[Yang, Xu] C

[Ma, Ping] H

Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Lab Environm Biomed, Coll Life Sci, Wuhan, Hubei, Peoples R China.

Hubei Univ Sci & Technol, Sch Basic Med Sci, Res Ctr Basic Med Sci, Xianning, Peoples R China.

语种：

英文

关键词：

Alzheimer's disease;air pollution;co-exposure;inflammation;oxidative stress

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

98567-98579

DOI：

10.18632/oncotarget.21637

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577045]; Hubei Province Health and Family Planning Scientific Research Project [WJ2017Z027]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Alzheimer's disease (AD) is a serious, common, global disease, yet its etiology and pathogenesis are incompletely understood. Air pollution is a multi-pollutants coexposure system, which may affect brain. The indoor environment is where exposure to both air particulate matter (< 2.5 μm in diameter) (PM2.5) and formaldehyde (FA) can occur simultaneously. Whether exposure to such a multi-pollutant (PM2.5 plus FA) mixture contributes to the development of AD, and whether there is a difference between exposure to PM2.5 or FA alone needs to be inve...

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At seeming safe concentrations, synergistic effects of PM2.5 and formaldehyde co-exposure induces Alzheimer-like changes in mouse brain

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