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Design, syntheses, and antitumor activity of novel chromone and aurone derivatives

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成果类型:
期刊论文
作者:
Huang, Wei;Liu, Ming-Zhen;Li, Yan*;Tan, Ying;Yang, Guang-Fu(杨光富
通讯作者:
Li, Yan
作者机构:
[Li, Yan] Wuhan Univ, Ctr Canc, Wuhan 430072, Peoples R China.
Wuhan Univ, Zhongnam Hosp, Wuhan 430072, Peoples R China.
Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430070, Peoples R China.
通讯机构:
[Li, Yan] W
Wuhan Univ, Ctr Canc, Wuhan 430072, Peoples R China.
语种:
英文
关键词:
Antitumor activity;Aurone;Chromone;Flavonoids;Microwave irradiation
期刊:
Bioorganic & Medicinal Chemistry
ISSN:
0968-0896
年:
2007
卷:
15
期:
15
页码:
5191-5197
基金类别:
The financial support of this work was from National NSFC (No. 20432010), New Century Excellent Talents Supporting Program of the Ministry of Education of China (NCET-04-0669), and Foundation for the Author of National Excellent Doctoral Dissertation of China (FANEDD-200464).
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
A series of new chromone analogues bearing heterocyclic thioether moiety and aurone analogues bearing cyclic tertiary amine moiety were designed and synthesized under microwave irradiation. The synthetic protocol was found to present many advantages, such as higher yields, shorter reaction time (10-20 min), mild condition, and readily isolation of the products. The synthesized compounds were assayed for their antitumor activity against four kinds of human solid tumor cell lines including HCCLM-7, Hep-2, MDA-MB-435S, and SW-480. Two compounds, (...

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