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Actinobacillus pleuropneumoniae FliY and YdjN are involved in cysteine/cystine utilization, oxidative resistance, and biofilm formation but are not determinants of virulence

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成果类型:
期刊论文
作者:
Zhao, Fan;Xu, Huan;Chen, Yubing;Xiao, Juan;Zhang, Miao;...
通讯作者:
Liu, Jinlin;Qi, C
作者机构:
[Xu, Huan; Zhang, Miao; Li, Zhuo; Liu, Jinlin; Zhao, Fan; Xiao, Juan; Qi, Chao; Chen, Yubing] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.
通讯机构:
[Liu, JL; Qi, C ] C
Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.
语种:
英文
关键词:
Actinobacillus pleuropneumoniae;FliY/YdjN;cysteine/cystine acquisition;Oxidative tolerance;Biofilm formation;Virulence
期刊:
Frontiers in Microbiology
ISSN:
1664-302X
年:
2023
卷:
14
页码:
1169774
基金类别:
This study was supported by grants from the Fundamental Research Funds for the Central Universities (CCNU19QN011 and CCNU19CG016) and the project of Hubei Key Laboratory of Genetic Regulation and Integrative Biology (GRIB201805).
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Introduction: Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a member of Actinobacillus in family Pasteurellaceae. It is the causative agent of porcine pleuropneumonia, which has caused huge economic losses to pig industry over the world. Cysteine is a precursor of many important biomolecules and defense compounds in the cell. However, molecular mechanisms of cysteine transport in A. pleuropneumoniae are unclear. Methods: In this study, gene-deleted mutants were generated and investigated, to reveal the roles of potential cysteine/cys...

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