期刊论文

Liu, Ke

英文

Journal of Molecular Biology

0022-2836

2020

432

6

1674-1686

10.1016/j.jmb.2019.09.025

This work is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) with funding reference number RGPIN-2016-06300 , the National Natural Science Foundation of China with funding reference number 31770834 , and also SGC. The SGC is a registered charity (number 1097737) that receives funds from AbbVie , Bayer Pharma AG , Boehringer Ingelheim , Canada Foundation for Innovation , Eshelman Institute for Innovation , Genome Canada through Ontario Genomics Institute [ OGI-055 ], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766 ], Janssen , Merck KGaA, Darmstadt, Germany , MSD , Novartis Pharma AG , Ontario Ministry of Research, Innovation and Science (MRIS) , Pfizer , São Paulo Research Foundation-FAPESP , Takeda , and Wellcome . Owing to the limited space, we apologize to those whose original work could not be cited in our review.

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CXXC domain-containing proteins are often involved in different biological processes, such as cell proliferation and development, apoptosis, DNA repair, signaling transduction, and tumorigenesis, by regulating transcription. 12 CXXC domain-containing proteins have been identified in human, and structural together with DNA binding studies reveal that these CXXC domains, a 50–70 residues module of two conserved CXXCXXC motifs, bind to non-methylated DNA in different sequence contexts. These CXXC domain-containing proteins and their complexes reg...