期刊论文

Inhibitive Effects of Lipoic Acid on Formaldehyde Induced DNA - protein Crosslink Formation in Mice Liver.

中文

医学研究杂志

1673-548X

2008

37

10

25-27

10.3969/j.issn.1673-548X.2008.10.009

基金项目：国家自然科学基金面上项目（30570799）

本校为第一机构

目的 探讨甲醛所致氧化损伤与DNA-蛋白质交联关系.方法 将昆明小鼠分3组:对照组,3.0mg/m3甲醛气体染毒组,3.0mg/m3甲醛气体染毒并注射α-硫辛酸(LA)组,处理后测定其肝脏谷胱甘肽(GSH)含量与DNA-蛋白质分子交联(DPC)系数.结果 吸入3.0mg/m3甲醛气体组小鼠肝脏中GSH含量显著下降,DPC系数显著增大;吸入3.0mg/m3甲醛气体染毒并注射LA组小鼠GSH含量恢复到正常水平,DPC系数也恢复到正常水平.结论 LA注射可抑制甲醛诱导小鼠肝细胞DPC的形成,DPC的产生与氧化损伤有一定的联系.

Objective To explore the relation between oxidative damage and DNA-protein crosslink caused by formaldehyde. Methods Kun Ming mice were divided into 3 groups： control group, 3.0mg/m^3 gaseous formaldehyde inhaled group, 3.0mg/m^3 gaseous formaldehyde and lipoic acid （LA） treated group. The content of GSH and the amount of DPC were measured after exposure to formaldehyde. Results The content of GSH in liver cell decline significantly and the amount of DPC increased significantly after inhaled with 3.0mg/m^3 gaseous formaldehyde. The content o...