One kind of nanosize titanium dioxide (nano-TiO2) was successfully made through anodization of titanium in this study, and its cytotoxicity and OS-mediated toxicity was detected by MTT, SOD and MDA assay in vitro and in vivo. The results showed that high does (0.8, 1.6 mg/mL) of this nano-TiO2 can cause cytotoxicity and OS-mediated toxicity, and reverse dose - rate effect happened in the low and medium does (0.1, 0.2, 0.4 mg/mL) i...