期刊论文

Wu, An-Xin（吴安心）

英文

Tetrahedron

0040-4020

2018

74

32

4323-4330

10.1016/j.tet.2018.06.047

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472056, 21602070, 21702091]; The Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU15ZX002]; 111 ProjectMinistry of Education, China - 111 Project [B17019]

本校为第一且通讯机构

An iodine-promoted fragment assembly strategy for the synthesis of fused heterocycles has been established. It provides an efficient route to construct pyrazolone-oxepine-pyrazoles from phenyl-hydrazines, aryl methyl ketones and acetoacetate esters. Notably, acetoacetate esters play two distinct pivotal roles in the five-component reaction by realizing the unique reactivities of methyl, methylene and carbonyl groups to construct 3-methyl-5-pyrazolone skeletons and by the reaction of methyl and carbonyl groups to form a...