Catalytic asymmetric dearomatization reactions of alpha-unsubstituted beta-naphthols are very challenging due to the high energy barrier resulting from the loss of aromaticity. Herein, we describe an example of enantioselective catalytic dearomative spiroannulation with yne-allylic esters. The success of this reaction relied on the copper-catalyzed remote asymmetric strategy using yne-allylic esters as the bis-electrophilic reagents. This transformation features mild reaction conditions, broad functional group tolerance, and an extensive substrate scope, thereby facilitating the efficient cons...
