期刊论文

Wu, An-Xin

英文

JOURNAL OF ORGANIC CHEMISTRY

0022-3263

2018

83

6

3409-3416

10.1021/acs.joc.8b00126

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472056, 21602070, 21772051]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU16A05002]; 111 ProjectMinistry of Education, China - 111 Project [B17019]

本校为第一且通讯机构

An efficient base-promoted C(sp3)–H bond functionalization strategy for the synthesis of multisubstituted chromans from the formal [3+3] cycloaddition of benzo[c]oxepines and electron-rich phenols has been developed. The corresponding 4H-chromenes can be easily obtained in excellent yields by simple filtration from chromans. Preliminary mechanistic studies indicate that the C–O bond cleavage is the key step for the C(sp3)–H bond functionalization and that this reaction could have occurred through tandem C...