Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Yue;Ding, Feng;Zhou, Zhixuan;Li, Chonglu;Pu, Maoping;...

通讯作者：

Li, Haibing;Yang, Guangfu;Sun, Yao;Stang, Peter J.

作者机构：

[Xu, Yuling; Sun, Yue; Yang, Guangfu; Li, Haibing; Yang, GF; Sun, Y; Sun, Yao; Li, Chonglu; Ding, Feng] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.

[Xu, Yuling; Sun, Yue; Yang, Guangfu; Li, Haibing; Yang, GF; Sun, Y; Sun, Yao; Li, Chonglu; Ding, Feng] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.

[Sun, Yue; Stang, Peter J.; Zhou, Zhixuan] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.

[Pu, Maoping] Rheinisch Westfalische Tech Hsch Aachen Univ, Inst Organ Chem, D-52074 Aachen, Germany.

[Lu, Xiaoju; Zhan, Yibei] Hubei Polytech Univ, Sch Chem & Chem Engn, Huangshi 435003, Peoples R China.

通讯机构：

[Li, HB; Yang, GF; Sun, Y] C

[Stang, Peter J.] U

Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.

Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.

语种：

英文

关键词：

*image-guided therapy;*metallacycle;*second near-infrared region;*supramolecular coordination complexes;*theranostic

期刊：

Proceedings of the National Academy of Sciences of the United States of America

ISSN：

0027-8424

年：

2019

卷：

116

期：

页码：

1968-1973

DOI：

10.1073/pnas.1817021116

基金类别：

National Key RD Program [2017YFA0505203]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21708012, 21572076, 21372092, 81371840, 51402099]; 111 ProjectMinistry of Education, China - 111 Project [817019]; self-determined research funds of Central China Normal University from the colleges; Wuhan Morning Light Plan of Youth Science and Technology [201705304010321]; Open Research Fund of Jiangsu Key Laboratory of Medical Optics Grant [JKLMO201803]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 CA215157]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01CA215157, R01CA215157, R01CA215157] Funding Source: NIH RePORTER

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0-1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Ou...

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Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

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