期刊论文

Zhao, Yunjie;Zeng, Chen

英文

BMC Bioinformatics

1471-2105

2019

20

1

1-12

10.1186/s12859-019-3099-4

This work is supported by the National Natural Science Foundation of China 11704140, Natural Science Foundation of Hubei 2017CFB116, and self-determined research funds of CCNU from the colleges’ basic research and operation of MOE CCNU19QD008 to YZ. The funders had no role in the design of the study, collection, analysis, interpretation of data, and writing the manuscript.

本校为第一且通讯机构

Background: It is widely believed that tertiary nucleotide-nucleotide interactions are essential in determining RNA structure and function. Currently, direct coupling analysis (DCA) infers nucleotide contacts in a sequence from its homologous sequence alignment across different species. DCA and similar approaches that use sequence information alone typically yield a low accuracy, especially when the available homologous sequences are limited. Therefore, new methods for RNA structural contact inference are desirable because even a single correct...