期刊论文

DIDP-Induced Liver Damage in Kunming Mice via Mitochondrial-Caspase Pathway

Li, R.

中文

环境科学研究

1001-6929

2018

31

11

1957-1964

10.13198/j.issn.1001-6929.2018.07.09

国家自然科学基金面上项目（No.21577045）~~；

本校为第一且通讯机构

为探究DIDP（Di-iso-decyl phthalate,邻苯二甲酸二异癸酯）对肝脏的影响及其可能的分子机制,以昆明小鼠为研究对象,选用Res（resveratrol,白藜芦醇）为抗氧化剂,分别设置对照组,0. 15、1. 5、15、150 mg/（kg·d）DIDP组,Res组,150 mg/（kg·d）DIDP+Res组,灌胃染毒9 d后,对小鼠肝脏切片进行HE染色观察,并检测ROS（reactive oxygen,活性氧）、GSH（glutathione,谷胱甘肽）、MDA（malondialdehyde,丙二醛）、Cyt-C（cytochromec,细胞色素C）、Caspase-3和血清中的ALT（alanine aminotransferase,丙氨酸氨基转移酶）含量.结果表明:与对照组相比,15、150 mg/（kg·d）DIDP组小鼠血清中ALT含量极显...

To elucidate the effect of Di-iso-decyl phthalate (DIDP) on mouse liver as well as the possible molecular mechanism, Kunming mice were used for the study and resveratrol (Res) was applied as an anti-oxidant to the mice, including the saline group, 0.15, 1.5, 15, 150 mg/(kg•d) DIDP groups, 20 mg/(kg•d) Res group and 150 mg/(kg•d) DIDP+20 mg/(kg•d) Res group. Mice were orally administrated with DIDP and/or Res for 9 consecutive days followed by execution for examination by HE staining and measurement of the content of ROS, GSH, MDA, Cyt-C, Ca...