Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin

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成果类型：

期刊论文

作者：

Ma, Ping;Liu, Xudong;Wu, Jiliang;Yan, Biao;Zhang, Yuchao;...

通讯作者：

Yang, Xu

作者机构：

[Wu, Yang; Liu, Chao; Wu, Jiliang; Ma, Ping] Hubei Univ Sci & Technol, Hubei Prov Key Lab Cardiovasc Cerebrovasc & Metab, Xianning 437100, Peoples R China.

[Yang, Xu; Zhang, Yuchao; Lu, Yu; Liu, Xudong; Yan, Biao; Guo, Junhui] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Lab Environm Biomed, Coll Life Sci, Wuhan 430079, Peoples R China.

[Bornehag, Carl-Gustaf; Nanberg, Eewa] Karlstad Univ, Dept Hlth Sci, Karlstad, Sweden.

[Zhang, Yuchao; Liu, Xudong] Moutai Univ, Dept Food Sci & Engn, Renhuai 564500, Peoples R China.

通讯机构：

[Yang, Xu] C

Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Lab Environm Biomed, Coll Life Sci, Wuhan 430079, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2015

卷：

期：

页码：

14676

DOI：

10.1038/srep14676

基金类别：

Hubei Province Natural Science Foundation Project [2014CFB284]; Key Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51136002]; China Key Technologies RD Program [2012BAJ02B03]; Hubei Natural Science Foundation Project for Outstanding Young Talents [2012FFA005]

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

Diisononyl phthalate (DINP) is a plasticizer that is frequently used as a substitute for other plasticizers whose use is prohibited in certain products. In vivo studies on the neurotoxicity of DINP are however, limited. This work aims to investigate whether DINP causes neurobehavioral changes in mice and to provide useful advice on preventing the occurrence of these adverse effects. Behavioral analysis showed that oral administration of 20 or 200 mg/kg/day DINP led to mouse cognitive deficits and anxiety. Brain histopathological observations, immunohistochemistry assays (cysteine-aspartic acid...

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Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin

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