Purpose: Whether formaldehyde induces DNA breakage or not is still in debate. So far it is not clear whether dose-effect between formaldehyde and DNA breakage takes place while the DPC exists. Approach: In this study we had chosen human buccal cells as materials to explore the genotoxicity of liquid and gaseous formaldehyde with comet assay. Findings: The results showed that liquid formaldehyde induced DNA breakage in the range from 5 μM to 10 μM (P＜0.05, compared with control group), and 7.5 μM was found to induce DNA breakage most. The DN...
