Research on the biology and chemistry of succinate dehydrogenase carried out in the authors’ laboratory was supported by the National Key Research and Development Program of China (No. 2017YFA0505200) and the National Natural Science Foundation of China (No. 21837001).
机构署名：
本校为第一且通讯机构
院系归属：
化学学院
摘要：
Succinate dehydrogenase (SDH) also known as complex II or succinate:quinone oxidoreductase is an enzyme involved in both oxidative phosphorylation and tricarboxylic acid cycle; the processes that generate energy. SDH is a multi-subunit enzyme which requires a series of proteins for its proper assembly at several steps. This enzyme has medical significance as there is a broad range of human diseases from cancers to neurodegeneration related to SDH malfunction. Some of these disorders have recently been linked to defective assembly factors, reinvigorating further research in this area. Apart fro...
