In this work, in order to identify the most effective measure and combinations of several measures to control influenza spread, we propose an SVEIAR influenza model with imperfect vaccination, media coverage and antiviral treatment. The global dynamics of the model is explored. Sensitivity analysis of the basic reproduction number and the endemic equilibrium is conducted to evaluate the effectiveness of influenza control measures. Furthermore, an optimal control problem incorporating the three measures is formulated to design optimal control strategies for influenza. The cost-effectiveness ana...
