期刊论文

Wu, An-Xin;Zhu, Yan-Ping

英文

Organic Letters

1523-7060

2020

22

18

7103-7107

10.1021/acs.orglett.0c02415

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21971080, 21971079, 21772051, 21702091]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU18QN011]; Science and Technology Innovation Development Plan of Yantai [2020MSGY114]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province

本校为第一且通讯机构

The first synthesis of arylquinazolinones has been disclosed via the consecutive oxidative cyclization/ring-opening of anilines and methyl ketones. This transformation is characterized by the splitting of the methyl ketone as acyl and C1 sources through C(CO)–C(sp3) bond cleavage, using DMSO as a C1 source via C–S bond cleavage, which expands the use of methyl ketones as valuable building blocks and enriches the library of preparation quinazolinones. Moreover, preliminary mechanistic studies indicate that this multicomponent...