Investigating the potential immune role of IL-35 in grass carp (Ctenopharyngodon idella)

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成果类型：

期刊论文

作者：

Zhang, Xiang-Yang;Cui, Zheng-Wei;Wu, Nan;Lu, Xiao-Bing;Lu, Long-Feng;...

通讯作者：

Zhang, Yong-An;Geng, Hui

作者机构：

[Zhang, Xiang-Yang; Lu, Xiao-Bing; Zhang, Yong-An; Wu, Nan; Chen, Dan-Dan; Lu, Long-Feng; Cui, Zheng-Wei] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China.

[Zhang, Yong-An] Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.

[Zhang, Yong-An] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China.

[Zhang, Xiang-Yang; Lu, Xiao-Bing; Cui, Zheng-Wei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Geng, Hui] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Zhang, Yong-An; Geng, Hui] C

Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China.

Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

*Cytokine;*Grass carp;*Heterodimer;*IL-35;*Immunosuppression

期刊：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

ISSN：

0145-305X

年：

2019

卷：

页码：

78-88

DOI：

10.1016/j.dci.2018.12.011

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2014CB138601]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472307]

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

Interleukin-35 (IL-35) is a member of the IL-12 cytokine family and a heterodimeric protein formed by Epstein-Barr virus-induced gene 3 (EBI3) and IL-12p35. Emerging evidence showed that IL-35 is a key player in the regulation of cellular communication, differentiation, and inflammation. To date, no studies on fish IL-35 have been documented. In this work, we first identify two splicing isoforms of EBI3, EBI3a and EBI3b, from grass carp (Ctenopharyngodon idella). EBI3a is composed of 299 amino acid residues and possesses an immunoglobulin-like ...

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Investigating the potential immune role of IL-35 in grass carp (Ctenopharyngodon idella)

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