期刊论文

Zhao, Yunjie

英文

BMC Bioinformatics

1471-2105

2019

20

1

1-11

10.1186/s12859-019-3254-y

This work is supported by National Natural Science Foundation of China 11704140 (YZ), 11775091(YJ), Natural Science Foundation of Hubei 2017CFB116 (YZ), and financially supported by self-determined research funds of CCNU from the colleges’basic research and operation of MOE CCNU19QD008 (YZ). The funders had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

本校为第一且通讯机构

BACKGROUND: The kinase pocket structural information is important for drug discovery targeting cancer or other diseases. Although some kinase sequence, structure or drug databases have been developed, the databases cannot be directly used in the kinase drug study. Therefore, a comprehensive database of human kinase protein pockets is urgently needed to be developed. RESULTS: Here, we have developed HKPocket, a comprehensive Human Kinase Pocket database. This database provides sequence, structure, hydrophilic-hydrophobic, critical interactions, and druggability information including 1717 pocket...