期刊论文

Lu, Liang-Qiu;Xiao, Wen-Jing

英文

Organic Letters

1523-7060

2018

20

22

7278-7282

10.1021/acs.orglett.8b03189

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21822103, 21820102003, 21772052, 21772053, 21572074, 21472057]; Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]; Foundation for the Author of National Excellent Doctoral Dissertation of PR ChinaFoundation for the Author of National Excellent Doctoral Dissertation of China [201422]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2017AHB047]

本校为第一且通讯机构

A catalyst-controlled acylation reaction of β-ketoesters was developed for the first time by combining visible-light photoactivation with Lewis acid or base catalysis. By employing a NiCl2·glyme complex with a bis(oxazoline) ligand as the Lewis acid catalyst, C-acylation products are exclusively achieved, while utilizing pyridine or DABCO as the Lewis base catalyst affords O-acylation products with complete regioselectivity. A range of β-ketoesters with satisfactory structural diversity were suitable for this transformation, demonstrating th...