期刊论文

Dilworth, David;Barsyte-Lovejoy, Dalia;Schapira, Matthieu;James, Lindsey, I

英文

Nature Chemical Biology

1552-4450

2022

18

1

56-63

10.1038/s41589-021-00898-0

The Structural Genomics Consortium is a registered charity (no. 1097737) that receives funds from AbbVie, Bayer AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genentech, Genome Canada through Ontario Genomics Institute (OGI-196), EU/EFPIA/OICR/McGill/KTH/Diamond Innovative Medicines Initiative 2 Joint Undertaking (EUbOPEN grant 875510), Janssen, Merck KGaA (also known as EMD in Canada and the United State), Merck & Co (also known as MSD outside Canada and the United States), Pfizer, Takeda and Wellcome (106169/ZZ14/Z). We acknowledge the Natural Sciences and Engineering Research Council of Canada (NSERC) for a postdoctoral fellowship awarded to D.D. This work was supported by the National Cancer Institute, NIH (grant R01CA242305) to L.I.J. M.S. gratefully acknowledges NSERC (grant RGPIN-2019-04416). Research in EpiCypher was supported by NIH grants R44GM117683 and R44GM116584. This work was supported by Cancer Research Society operating grant (25418) to D.B.-L. We thank T. Hajian for purifying proteins and L. Halabelian for providing fluorescein-labeled dsDNA. We thank the University of North Carolina’s Department of Chemistry Mass Spectrometry Core Laboratory, especially D. Wallace, for their assistance with MS analysis. The Mass Spectrometry Core Laboratory is supported by the National Science Foundation under grant number CHE-1726291. Research reported in this publication was supported, in part, with funding by the University of North Carolina’s School of Medicine Office of Research. We thank F. Potjewyd for reviewing the primary synthesis data supporting this manuscript. Receptor-, channel-and transporter-binding profiles were generously provided by the National Institute of Mental Health’s Psychoactive Drug Screening Program, contract number HHSN-271-2018-00023-C (NIMH PDSP). The NIMH PDSP is directed by B.L. Roth at the University of North Carolina at Chapel Hill and Project Officer J. Driscoll at NIMH, Bethesda MD, USA. For experimental details, please refer to the PDSP web site at https://pdsp.unc.edu/ims/investigator/web/.

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