期刊论文

Yu, Xiao-Qiang

英文

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

0145-305X

2019

95

1

50-58

10.1016/j.dci.2019.01.017

The authors thank Professor Y. Tony Ip at the University of Massachusetts Medical School, Worcester, MA, for his critical comments on the manuscript. This work was supported by the National Natural Science Foundation of China (No. 31472019 ). Appendix A

本校为其他机构

An important innate immune response in Drosophila melanogaster is the production of antimicrobial peptides (AMPs). Expression of AMP genes is mediated by the Toll and immune deficiency (IMD) pathways via NF-kappaB transcription factors Dorsal, DIF and Relish. Dorsal and DIF act downstream of the Toll pathway, whereas Relish acts in the IMD pathway. Dorsal and DIF are held inactive in the cytoplasm by the IkappaB protein Cactus, while Relish contains an IkappaB-like inhibitory domain at the C-terminus. NF-kappaB factors normally form homodimers and heterodimers to regulate gene expression, but ...