期刊论文

Lu, Liang-Qiu;Xiao, Wen-Jing

英文

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1433-7851

2019

58

8

2402-2406

10.1002/anie.201813689

We are grateful to the National Science Foundation of China (No. 21822103, 21820102003, 21772052, 21772053, 21572074, and 21472057), the Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019), the International Joint Research Center for Intelligent Biosensing Technology and Health, and the Natural Science Foundation of Hubei Province (2017AHB047) for support of this research.

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The palladium-catalyzed Heck reaction is a well-known, Nobel Prize winning transformation for producing alkenes. Unlike the alkenyl and aryl variants of the Heck reaction, the alkyl-Heck reaction is still underdeveloped owing to the competitive side reactions of alkyl–palladium species. Herein, we describe the development of a deaminative alkyl-Heck-type reaction that proceeds through C−N bond activation by visible-light photoredox catalysis. A variety of aliphatic primary amines were found to be efficient starting materials for this new proc...